Research Article

NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway

Figure 1

Effects of NBD on LPS-induced pulmonary histopathological changes in mice with ALI. (a) Lung sections stained with hematoxylin-eosin at 2 hours after LPS administration exhibited pulmonary histopathological changes (original magnification ×200). (A) Control group: normal structure. (B) Model group: alveolar wall thickening, hemorrhaging, alveolar collapse, and obvious inflammatory cell infiltration. (C) N-NBD group: same as the model group. (D) NBD-2 group. (E) NBD-6 group. (F) NBD-10 group. (b) Lung wet/dry weight ratios, (c) alveolar wall thickness, and (d) histopathological changes were evaluated to assess lung injury severity. LPS-induced lung injury severity was attenuated by NBD in a dose-dependent manner. Data are expressed as the mean ± SD (n = 6). A represents versus control group, < 0.05; represents versus model group, 0.05; C represents versus N-NBD group, < 0.05; represents versus NBD-2 group, < 0.05.
(a)
(b)
(c)
(d)