Research Article

NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway

Figure 7

Effect of NBD on pNF-κBp65 expression, as determined via immunohistochemistry, in the lung tissues of mice with ALI. (a) Representative photographs of pNF-κB P65 expression in the lung (original magnification ×200). (A) Control group; (B) model group; (C) N-NBD group; (D) NBD-2 group; (E) NBD-6 group; (F) NBD-10 group. Black arrows indicate the immunohistochemically positive pNF-κBp65. (b) IHC staining scores pertaining to pNF-κB P65 expression. pNF-κBp65 expression levels were increased by LPS administration, and these changes were inhibited by NBD pretreatment in a concentration-dependent manner. Data are expressed as the mean ± SD (n = 6). represents versus control group, < 0.05; represents versus model group, < 0.05; represents versus N-NBD group, < 0.05; represents versus NBD-2 group, < 0.05.
(a)
(b)