Extra-Articular Symptoms in Constellation with Selected Serum Cytokines and Disease Activity in Spondyloarthritis

Table 2

Comparison of serum levels of selected cytokines and markers of disease activity in spondyloarthritis patients with and without acute anterior uveitis and inflammatory bowel disease.

	AAU; present	AAU; absent		IBD; present	IBD; absent
Age (years)		48.9	0.06			0.1
Disease duration (years)	10.0; (5.0, 19.0)	5.0; (2.0, 9.0)	0.0002	10.0; (5.0, 13.5)	5.0; (2.0, 10.)	0.06
HLA-B27		47.1	0.0001	100	62	0.04
VAS pain (mm)			0.0008			0.03
BASDAI			0.0001	5.3	4.2	0.1
ASDAS-ESR	2.7; (2.2, 3.4)	2.3; (1.8, 3.0)	0.04	3.1; (2.2, 4.1)	2.4; (1.8, 3.2)	0.06
DAS28	0.0	4.24	<0.0001	0.0	4.24	<0.0001
CRP (mg/L)	10.5; (2.6, 21.1 0)	5.0; (2.0, 11.4)	0.006	19.0; (7.8, 31.1)	5.5; (2.1, 12.3)	0.0009
ESR (mm/h)	14.0; (5.0, 35.)	13.5; (6.0, 24.5)	0.4	25.5	14.0	0.05
IL-6 (pg/mL)	4.5; (1.5, 10.1)	2.9; (1.5, 6.5)	0.02	3.3; (1.5, 6.4)	2.9; (1.5, 20.7)	0.0003
IL-18 (pg/mL)	323.5; (228.7, 454.5)	271.8; (203.5, 346.2)	0.03	333.8; (237.5, 285.2)	271.8; (207.3, 373.9)	0.4
IL-23(pg/mL)	0.0; (0.0, 2.8)	0.0; (0.0, 1.8)	0.2	0.0; (0.0, 0.3)	0.0; (0.0, 2.0)	0.2
VEGF (pg/mL)	406.2; (270.0, 880.0)	343.1; (223.2, 545.7)	0.05	341.3; (206.3, 505.0)	347.4; (225.9, 562.2)	0.3
EGF (pg/mL)	115.0; (62.0, 182.0)	104.0; (68.0, 168.0)	0.5	81.0; (32.0, 141.0)	104.0; (68.0, 182.0)	0.2
ET-1 (pg/mL)			0.07			0.3

Data are presented as mean ± standard deviation, median (Q1 and Q3). AAU: acute anterior uveitis, ASDAS-ESR: Ankylosing Spondylitis Disease Activity Score, BASDAI: Bath Ankylosing Spondylitis Disease Activity Index, CRP: C-reactive protein, DAS28: Disease Activity Score 28, EGF: epidermal growth factor, ESR: erythrocyte sedimentation rate, ET-1: endothelin-1, IBD: inflammatory bowel disease, IL-6: interleukin-6, IL-18: interleukin-18, IL-23: interleukin-23, VAS pain: visual analogue scale of patient’s pain, and VEGF: vascular endothelial growth factor.