miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis

Figure 1

The relative expression of miR-155 in macrophages RAW264.7 cells and the aortic tissue of ApoE^−/− mice. (a) qPCR analyzed the expression of miR-155 in RAW264.7 cells when macrophages were treated by ox-LDL for 24 h at the indicated dose: , relative to control, , relative to 5 μg/mL ox-LDL group, , relative to 10 μg/mL ox-LDL group. (b) qPCR detected the level of miR-155 in macrophages, which were treated with 20 μg/mL ox-LDL at the indicated time: , relative to control, , relative to 6 h group, , relative to 12 h group. (c) Expression of miR-155 in aortic tissue of ND-fed wild-type (WT) c57 mice, ND-fed ApoE^−/− mice (ApoE^−/− ND), and HFD-fed ApoE^−/− mice (ApoE^−/− HFD) was determined by qPCR (): , relative to c57 mice WT; , relative to ApoE^−/− ND.

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