Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ^12,14-Prostaglandin J₂ (15d-PGJ₂) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4⁺CD25⁻FOXP3⁺ Cells

Figure 1

15d-PGJ₂ attenuated collagen-induced arthritis. PPAR-γ mRNA expression was quantified by real-time PCR in draining lymph nodes from naïve (white bar) or collagen-immunized and challenged DBA/1 (black bar) mice on the seventh day of disease (a). Arthritic mice were treated by the subcutaneous route with vehicle (○) or 15d-PGJ₂ (1 mg/Kg) (●) for 7 d. Mice were monitored for disease progression as indicated by clinical scores (b), number of affected paws (c), hypernociception (d), and edema (e). Results are presented as the mean ± SEM, N = 8–10; compared with the PBS-treated group.

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