Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ^12,14-Prostaglandin J₂ (15d-PGJ₂) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4⁺CD25⁻FOXP3⁺ Cells

Figure 3

Decreased inflammatory cytokines in articular joints from 15d-PGJ₂-treated arthritic mice. Ankle joints from naïve () or PBS- (○) or 15d-PGJ₂-treated (●) arthritic mice were collected after 7 days of treatment for the determination of TNF-α (b), IFN-γ (d), IL-17 (c), and IL-12 (a) levels by ELISA in the homogenate supernatants. Results are expressed as the mean ± SEM, N = 4 (naïve) and 9-10 (arthritic groups). compared with naïve group. compared with arthritic mice treated with PBS (vehicle).

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