Th17 Cytokines Disrupt the Airway Mucosal Barrier in Chronic Rhinosinusitis

Figure 1

The Th17 cytokines IL-17, IL-22, and IL-26 cause a time-dependent reduction in TEER. Effect of Interferons , , and and of Th1, Th2, and Th17 cytokines on epithelial barrier function determined by measuring transepithelial electrical resistance (TEER) before the addition of cytokines (), and after 4 and 24 h. The values are shown as mean ± SEM for . Treatments significantly different from the untreated control at are presented as . ANOVA, followed by Tukey HSD post hoc test.