Simultaneous Inhibition of PGE₂ and PGI₂ Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models

Figure 2

Induction of prostanoids synthesis and inhibitory profile of compound A in rat peritoneal macrophages. (a) The production of PGE₂, 6-keto , , and TXB₂ with or without LPS treatment. (b) to (e) Dose-dependent effects of compound A on the production of PGE₂ (b), 6-keto (c), (d), and TXB₂ (e) in rat macrophages. (f) Dose-dependent effects of celecoxib on the production of PGE₂, 6-keto , , and TXB₂ in rat macrophages. Results are shown as the mean ± SD (in duplicate). A representative result from reproduced experiments is shown.

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