Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine

Figure 6

Behavioral performance in the Y-maze of WT and MK−/− mice treated with amphetamine during adolescence. (a) Figure shows mean ± SEM of discrimination ratio for 6-week-old WT and MK−/− mice pretreated with amphetamine during adolescence. Significant effects of the genotype (F_(1,44) = 5.04, ) and the treatment (F_(1,44) = 6.03, ) were found. (b) Figure shows mean ± SEM of discrimination ratio for 7-week-old WT and MK−/− mice pretreated with amphetamine. Significant effects of the genotype (F_(1,44) = 5.1, ) and treatment (F_(1,44) = 10.46, ) were found. (c) Figure shows mean ± SEM of discrimination ratio for 9-week-old WT and MK−/− mice pretreated with amphetamine. versus WT.

(a) Six weeks old

(b) Seven weeks old

(c) Nine weeks old