CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis

Figure 5

CpG-A treatment increases CD4+ Foxp3 Treg cell differentiation in EAE mice. (a) Flow cytometry analysis of CD4⁺ and Foxp3⁺ Treg cells in the spleen of specific groups (indicated) at the peak of disease. Numbers represent percentages of double positive cells. Data are representative of one of two independent experiments. (b) CD4⁺FoxP3⁺ T cell quantification in the spleens of mice treated with PBS or CpG-A. Mean ± sem; CpG-A versus PBS, and two-tailed Mann–Whitney test.

(a)

(b)