IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes

Figure 5

IL-34 increased the expression of inflammatory chemokines in RA FLS. RA FLS () were stimulated with or without IL-34 (50 ng/ml) for 72 h, and the supernatants of RA FLS were detected with the protein chip AAH-CYT-G1000 kits. (a) Four chemokines (ENA-78, GRO, IL-8, and MCP-1) with obvious enhanced brightness after being incubated with IL-34 (right part) for 72 h were picked out for further analysis. (b) The secretion levels of the four chemokines were analyzed in RA FLS supernatant with or without IL-34 stimulation. Data represents the mean ± SEM. .

(a)

(b)