Immunomodulation of RA Patients’ PBMC with a Multiepitope Peptide Derived from Citrullinated Autoantigens

Figure 4

Cit-ME upregulates Treg in vitro. (a) Representative dot plot of CD4⁺Foxp3⁺ T cells from a RA patient. Positive staining is presented in the right upper quadrant of each graph with the percentage indicated. (b) The fold change of % CD4⁺Foxp3⁺ T cells determined by flow cytometry (). Data are presented as mean values (, ). (c) Histogram shows representative Foxp3 staining for one RA patient, gated for CD4⁺ T cells. (d) Representative dot plot of RA patient PBMC gated for CD4 and analyzed for CD25 and Foxp3 expression.

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