Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

Figure 4

Cytokine and chemokine levels as well as neutrophil counts in peritoneal lavage fluid (PLF) of wild-type, gzmA^−/−, gzmB^−/−, and gzmAxB^−/− mice during E. coli peritonitis. Mice were infected intraperitoneally with CFU E. coli and sacrificed at 6, 14, and 20 h after infection. Data are box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation.  = 7-8 per group at each time point. and determined by Mann–Whitney U test. Dotted lines represent lower detection limits. NA: not available.

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