Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

Table 1

Plasma levels of ASAT, ALAT, LDH, creatinine and urea, and PLF levels of nucleosomes from wild-type and gzmA^−/−, gzmB^−/−, and gzmAxB^−/− mice at late stage E. coli peritonitis (20 h).

	WT	gzmA^−/−	gzmB^−/−	gzmAxB^−/−
ASAT (U/ml)	2.7 (2.3–3.1)	3.3 (0.8–4.4)	1.4 (0.5–5.0)	2.1 (1.4–3.0)
ALAT (U/ml)	0.7 (0.4–0.9)	1.2 (0.3–1.3)	0.6 (0.05–1.3)	0.6 (0.4–0.9)
LDH (U/ml)	3.0 (2.7–4.9)	3.2 (0.5–5.3)	1.6 (0.8–2.9)	1.6 (0.6–4.9)
Creatinine (μmol/l)	6.7 (6.2–7.6)	10.4 (7.7–13.3)	20.3 (15.9–21.0)^#	12.1 (8.9–20.0)
Urea (nmol/l)	8.5 (8.1–10.6)	12.6 (8.6–14.4)	14.0 (13.6–18.6)	11.7 (7.8–13.8)
Nucleosomes (U/ml)	0.8 (0.8–0.8)	10.4 (2.2–21.5)	6.2 (4.0–9.1)	8.2 (4.7–10.6)

Values are median (interquartile range) from 6–8 mice per group 20 h after infection with CFU E. coli. PLF: peritoneal lavage fluid. versus WT, versus WT, ^# versus gzmA^−/− by Mann–Whitney U test.