Research Article

Protective Effects of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, against Cisplatin-Induced Nephrotoxicity in Mice

Figure 5

Effects of gemigliptin pretreatment on cisplatin-induced inflammatory responses. Plasma levels of TNF-α (a) and MCP-1 (b). (c) Immunohistochemical staining of nuclear NF-κB p65 in the kidneys (×200). Red arrows indicate cells showing nuclear p65-positive staining. (d) The number of NF-κB-activated cells in 10 fields (×200). Con: control, ; CP: cisplatin, ; and CP + G: cisplatin + gemigliptin, . All data are expressed as the mean ± SEM. # versus Con, versus CP, and versus CP.
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