Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy

Figure 6

Regulation of gene expression by IFN-α in human mesangial cells. Human mesangial cells were subjected to serum starvation for 6 h, followed by IFN-α treatment (4000 IU/ml) for varied time points (0 min, 2 h, and 6 h). The mRNA levels of TGF-beta, VEGFA, RANTES, ICAM, IL-6, IFNAR1, IP-10, iNOS, TNF-α, IL-1β, PDGF-BB, and MCP-1 were measured by real-time PCR. This experiment was repeated independently at least three times, and representative data are shown. , , and .