Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy

Table 2

Association of pDC and IFN-alpha with clinical parameters and renal histopathology in IgAN patients.

Feature	pDC percentage in PBMCs		IFN-alpha protein levels in plasma
	Pearson’s r	value	Pearson’s r	value
Age (yr)	0.05	0.76	0.15	0.39
Serum creatinine (μM)	0.027	0.88	−0.09	0.58
eGFR (ml/min per 1.73 m^2)	0.005	0.99	−0.02	0.91
24-hour proteinuria (g/24 h)	0.11	0.53	0.34	0.04
Serum IgA (g/l)	−0.29	0.09	0.07	0.69
Serum IgG (g/l)	0.03	0.85	0.05	0.78
Serum IgM (g/l)	0.22	0.29	0.08	0.67
Serum C3 (g/l)	0.14	0.48	−0.16	0.36
CRP (mg/l)	0.33	0.09	−0.12	0.49
SAA (mg/l)	0.27	0.16	−0.11	0.51
ASO (Ku/l)	0.31	0.11	0.22	0.20
Anti-Dnase B (U/ml)	−0.21	0.28	0.48	0. 005
Mesangail hypercellularity (M0/M1)	0.09	0.62	−0.07	0.69
Endocapillary hypercellularity (E0/E1)	0.04	0.84	−0.06	0.63
Tubular atrophy/ interstitial fibrosis (T0/T1/T2)	0.03	0.89	0.37	0.03
Segmental sclerosis (S0/S1)	0.17	0.33	0.11	0.52
Kidney IgA intensity	−0.23	0.20	0.03	0.85
Kidney IgG intensity	0.11	0.55	−0.04	0.81
Kidney IgM intensity	0.45	0.009	0.34	0.04
Kidney C3 intensity	−0.30	0.09	0.15	0.40

C3: complement 3; CRP: C-reactive protein; SAA: serum amyloid A protein; ASO: antistreptolysin O. ; .