Research Article
Administration of FTY720 during Tourniquet-Induced Limb Ischemia Reperfusion Injury Attenuates Systemic Inflammation
Figure 2
Mean peripheral blood WBC, neutrophil, and lymphocyte counts following tourniquet-induced hind limb IRI. Rats underwent hind limb ischemia by placement of a tourniquet band for 4 hr followed by reperfusion of affected limb. Rats received a single intravenous bolus of either vehicle control (•) or 0.3 mg/kg FTY720 (■) 15 min after placement of the tourniquet. Animals were euthanized at 6, 24, or 72 hr postinjury as indicated. Blood was collected by cardiac puncture for leukocyte differential counts. Data are shown as the average number of cells for each treatment group ± SEM (n = 7–10 rats per time point/group). compared with vehicle control at the same time point postinjury.
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