Gαq Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation

Figure 4

Loss of Gαq enhances the activation of STAT4. Purified naïve CD4⁺ T cells from WT and Gnaq−/− mice were stimulated under Th1 induction condition for 10 minutes. Cells were harvested, fixed, permeabilized, and stained with PE-conjugated anti-p-STAT4 and analyzed by flow cytometry. Data are representative of three independent experiments with similar results.