Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Table 1

Arterial blood gases at the end of reperfusion (, ).

	Group SM	Group IR	Group F3	Group F5	Group F10
pH	7.36 ± 0.16	7.18 ± 0.11	7.24 ± 0.09	7.30 ± 0.12	7.35 ± 0.15^#
PaO2 (mmHg)	260 ± 54	148 ± 44	185 ± 20	228 ± 53	253 ± 58^#
PaCO2 (mmHg)	45 ± 8	70 ± 10	62 ± 6	51 ± 6	48 ± 5^#
BE (mM)	−2.9 ± 1.2	−9.9 ± 2.1	−7.2 ± 1.5	−5.9 ± 1.2	−3.5 ± 1.3^#

Rats were divided into five groups: groups SM, IR, F3, F5, and F10. The rats in group SM received sham operation and bilateral limb IR (ischemia 3 h/reperfusion 3 h) in group IR. The rats in groups F3, F5, and F10 were treated with FTY720 3 mg/kg/d, 5 mg/kg/d, and 10 mg/kg/d, respectively, for 7 consecutive days before limb IR. Upon 3 h reperfusion, arterial blood gases were analyzed. PaO₂: arterial partial pressure of oxygen; PaCO₂: arterial partial pressure of carbon dioxide; BE: base excess. versus group SM; ^# versus group IR.