Research Article

Effects of FTY720 on Lung Injury Induced by Hindlimb Ischemia Reperfusion in Rats

Table 1

Arterial blood gases at the end of reperfusion (, ).

Group SMGroup IRGroup F3Group F5Group F10

pH7.36 ± 0.167.18 ± 0.117.24 ± 0.097.30 ± 0.127.35 ± 0.15#
PaO2 (mmHg)260 ± 54148 ± 44185 ± 20228 ± 53253 ± 58#
PaCO2 (mmHg)45 ± 870 ± 1062 ± 651 ± 648 ± 5#
BE (mM)−2.9 ± 1.2−9.9 ± 2.1−7.2 ± 1.5−5.9 ± 1.2−3.5 ± 1.3#

Rats were divided into five groups: groups SM, IR, F3, F5, and F10. The rats in group SM received sham operation and bilateral limb IR (ischemia 3 h/reperfusion 3 h) in group IR. The rats in groups F3, F5, and F10 were treated with FTY720 3 mg/kg/d, 5 mg/kg/d, and 10 mg/kg/d, respectively, for 7 consecutive days before limb IR. Upon 3 h reperfusion, arterial blood gases were analyzed. PaO2: arterial partial pressure of oxygen; PaCO2: arterial partial pressure of carbon dioxide; BE: base excess. versus group SM; # versus group IR.