IL-1β-Induced Accumulation of Amyloid: Macroautophagy in Skeletal Muscle Depends on ERK

Figure 5

Model of regulation of macroautophagy in skeletal muscle via IL-1β + IFN-γ and ERK. Green arrows depict findings of the present manuscript: IL-1β + IFN-γ activates the ERK pathway. Phosphorylated ERK contributes to an upregulation of autolysosomal turnover, which is followed by accumulation of protein. Previously known pathways are marked by grey arrows, including an upregulation of APP upon exposure to IFN-γ + IL-1β and followed by generation of β-amyloid and accumulation of protein. It is known that macroautophagy contributes to production of β-amyloid.