Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice

<div>Effect of the anti-IL-22 nAb on angiotensin II-induced cardiac fibrosis. (a) Cardiac interstitial fibrosis was determined in the heart sections from each group by PSR straining, <i>n</i> = 4-5 for each group. (b) Ratios of fibrotic areas on histological sections were quantified by an image-analysis system. (c) The mRNA expression levels of fibronectin, CTGF, collagen I<i>α</i>, collagen III<i>α</i>, and TGF-<i>β</i> in the myocardium of each group were determined by RT-qPCR, <i>n</i> = 3-4 for each group. <svg height="13.532pt" id="M23" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 50.6052 13.532" width="50.6052pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 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50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path></g></svg> versus Ang II group.</div>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice 