Platelet-Released Growth Factors Induce Differentiation of Primary Keratinocytes

Figure 6

PRGF-treated primary human keratinocytes display morphologic features typical for keratinocytes in their late terminal differentiation phase. During all in vitro experiments, PRGF-treated primary human keratinocytes revealed a morphology that is a characteristic for keratinocytes undergoing terminal differentiation such as growth in several layers and loss of distinct cell borders. Shown are untreated primary human keratinocytes cultured for 24 hours (a) and 48 hours (c) compared to primary human keratinocytes treated with PRGF (1 : 10) for 24 hours (b) and 48 hours (d).

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