Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study
Table 4
Association between EBI3 and IL-12A gene polymorphisms and metabolic abnormalities in premature coronary artery disease patients.
Polymorphism
Genotype frequency (%)
MAF
Model
OR [95% CI]
(i) EBI3
rs428253
G>C
GG
GC
CC
Alanine aminotransferase > p75
Additive
1.330 [1.083–1.632]
0.006
No ()
401 (0.679)
167 (0.283)
22 (0.038)
0.179
Dominant
1.429 [1.121–1.821]
0.004
Si ()
340 (0.594)
204 (0.357)
28 (0.049)
0.227
Heterozygote
1.392 [1.084–1.787]
0.010
Codominant 1
1.425 [1.107–1.835]
0.006
Aspartate aminotransferase > p75
No ()
489 (0.650)
238 (0.316)
25 (0.034)
0.191
Codominant 2
1.823 [1.022–3.250]
0.042
Si ()
251 (0.613)
135 (0.328)
24 (0.059)
0.223
Type 2 diabetes mellitus
Dominant
0.753 [0.580–0.978]
0.033
No ()
458 (0.611)
259 (0.345)
33 (0.044)
0.217
Heterozygote
0.727 [0.554–0.954]
0.022
Si ()
282 (0.684)
112 (0.272)
18 (0.044)
0.180
Codominant 1
0.726 [0.522–0.955]
0.022
rs4905
A>G
AA
AG
GG
Alanine aminotransferase > p75
Additive
1.241 [1.031–1.495]
0.023
No ()
400 (0.532)
302 (0.402)
50 (0.066)
0.267
Dominant
1.309 [1.037–1.653]
0.024
Si ()
212 (0.517)
162 (0.394)
36 (0.089)
0.285
Codominant 1
1.284 [1.006–1.640]
0.045
(ii) IL-12A
rs2243123
T>C
TT
TC
CC
Type 2 diabetes mellitus
No ()
290 (0.387)
358 (0.477)
102 (0.137)
0.375
Recessive
1.148 [1.061–2.063]
0.021
Si ()
150 (0.365)
182 (0.441)
80 (0.194)
0.415
Codominant 2
1.511 [1.048–2.178]
0.028
rs2243115
T>G
TT
TG
GG
Metabolic syndrome
Additive
0.591 [0.386–0.905]
0.015
No ()
286 (0.875)
40 (0.122)
1 (0.003)
0.064
Dominant
0.590 [0.381–0.912]
0.017
Si ()
762 (0.913)
72 (0.086)
1 (0.001)
0.044
Heterozygote
0.599 [0.386–0.929]
0.022
Codominant 1
0.592 [0.385–0.927]
0.021
rs583911
A>G
AA
AG
GG
Inflammation
No ()
255 (0.274)
433 (0.466)
242 (0.260)
0.493
Recessive
0.633 [0.435–0.921]
0.017
Si ()
67 (0.287)
123 (0.532)
42 (0.181)
0.446
Aspartate aminotransferase > p75
Additive
1.236 [1.046–1.460]
0.013
No ()
211 (0.296)
343 (0.482)
158 (0.222)
0.463
Dominant
1.318 [1.004–1.730]
0.046
Si ()
109 (0.242)
217 (0.483)
124 (0.275)
0.517
Recessive
1.344 [1.021–1.769]
0.035
Codominant 2
1.529 [1.096–2.133]
0.013
GGT > p75
No ()
178 (0.285)
309 (0.494)
138 (0.221)
0.468
Recessive
1.329 [1.011–1.748]
0.042
Si ()
141 (0.263)
251 (0.468)
145 (0.269)
0.504
Table shows the models with significant associations. Models were adjusted for age, gender, and body mass index. MAF: minor allele frequency; GGT: gamma-glutamyl transferase.
