Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study
Table 5
Association between EBI3 and IL-12A gene polymorphisms and metabolic abnormalities in the control group.
Polymorphism
Genotype frequency (%)
MAF
Model
OR [95% CI]
(i) EBI3
rs428253
G>C
GG
GC
CC
Hyperuricemia
No ()
454 (0.625)
220 (0.303)
52 (0.072)
0.223
Heterozygote
1.595 [1.064–2.389]
0.024
Si ()
82 (0.555)
57 (0.390)
8 (0.055)
0.248
Codominant 1
1.567 [1.038–2.365]
0.032
rs4740
G>A
GG
GA
AA
Central obesity
No ()
99 (0.503)
78 (0.400)
19 (0.097)
0.296
Heterozygote
0.391 [0.163–0.937]
0.035
Si ()
377 (0.557)
251 (0.371)
49 (0.072)
0.258
Codominant 2
0.386 [0.157–0.949]
0.038
AST > p75
Additive
1.250 [1.004–1.557]
0.046
No ()
327 (0.576)
197 (0.348)
43 (0.076)
0.250
Dominant
1.430 [1.076–1.899]
0.014
Si ()
148 (0.485)
133 (0.433)
25 (0.082)
0.299
Heterozygote
1.433 [1.073–1.913]
0.015
Codominant 1
1.473 [1.093–1.985]
0.011
rs4905
A>G
AA
AG
GG
Central obesity
No ()
99 (0.503)
78 (0.400)
19 (0.097)
0.296
Recessive
0.404 [0.170–0.960]
0.040
Si ()
374 (0.552)
253 (0.371)
50 (0.074)
0.261
Codominant 2
0.403 [0.165–0.983]
0.046
AST > p75
Dominant
1.399 [1.054–1.858]
0.020
No ()
324 (0.571)
199 (0.352)
44 (0.078)
0.253
Heterozygote
1.410 [1.056–1.882]
0.020
Si ()
148 (0.485)
133 (0.433)
25 (0.082)
0.299
Codominant 1
1.445 [1.072–1.946]
0.016
(ii) IL-12A
rs568408
G>A
GG
GA
AA
Metabolic syndrome
No ()
542 (0.883)
69 (0.112)
3 (0.005)
0.061
Additive
0.583 [0.347–0.981]
0.042
Si ()
237 (0.915)
21 (0.081)
1 (0.004)
0.044
rs583911
A>G
AA
AG
GG
SAT > p75
No ()
129 (0.268)
222 (0.459)
132 (0.273)
0.503
Heterozygote
1.776 [1.203–2.622]
0.004
Si ()
88 (0.226)
220 (0.563)
82 (0.211)
0.492
Codominant 1
1.776 [1.107–2.849]
0.017
Table shows the models with significant associations. Models were adjusted for age, gender, and body mass index. MAF: minor allele frequency, AST: aspartate aminotransferase, and SAT: subcutaneous adipose tissue.
