Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study
Table 6
Interleukin 35 plasma concentrations in the study groups according to the EBI3 and IL-12A polymorphisms.
Polymorphism
Genotype
Controls ()
pCAD ()
Concentration (pg/mL)
Concentration (pg/mL)
(i) EBI3
rs428253
GG
275
2.72 [0.88–4.97]
286
3.16 [1.03–6.51]
GC
151
3.00 [1.62–5.23]
0.273
140
3.40 [1.19–7.76]
0.433
CC
21
1.98 [0.19–5.10]
21
2.20 [1.63–3.78]
rs4740
GG
250
2.52 [0.88–4.50]
233
3.23 [1.62–7.61]
GA
160
3.00 [1.63–5.23]
0.020
185
3.16 [0.95–6.15]
0.311
AA
37
3.40 [0.88–7.90]
29
3.16 [1.62–5.23]
rs4905
AA
248
2.52 [0.88–4.40]
233
3.23 [1.62–7.61]
AG
164
3.00 [1.63–5.23]
0.017
186
3.16 [0.95–6.15]
0.338
GG
35
3.78 [0.88–7.90]
28
3.08 [1.62–5.23]
(ii) IL12A
rs2243115
TT
389
2.72 [0.88–4.97]
407
3.16 [1.62–6.44]
TG + GG
58
3.08 [0.83–5.23]
0.376
40
3.56 [0.38–7.95]
0.985
rs568408
GG
398
2.81 [0.88–4.97]
396
3.23 [1.62–6.74]
GA + AA
49
2.32 [0.31–7.17]
0.763
51
2.72 [0.95–6.44]
0.254
rs2243123
TT
188
2.72 [0.59–4.97]
183
3.40 [1.03–7.09]
TC
198
2.90 [0.88–5.23]
0.702
190
3.00 [1.62–6.31]
0.714
CC
61
3.00 [0.88–5.23]
74
3.32 [1.47–8.38]
rs583911
AA
113
3.00 [0.88–5.23]
130
3.23 [1.30–8.56]
AG
224
2.90 [0.88–5.23]
0.570
194
3.00 [0.95–6.19]
0.215
GG
110
2.46 [0.88–4.82]
123
3.40 [1.62–7.09]
Data are shown as median [interquartile range]. Comparisons were made using Mann–Whitney test or Kruskal-Wallis test as appropriate. Italic numbers indicate significant associations. pCAD: premature coronary artery disease.
