The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes

Figure 5

HBD-3 is induced by Vivostat PRF treatment in vivo. In the in vivo study, we observed a strong hBD-3 gene induction by artificial wound generation which was significantly increased by local wound therapy by Vivostat PRF (a) (, , Student’s t-test). (b) Correspondingly, using immunohistochemistry, we observed a strong hBD-3 induction in the uppermost epidermal layers of artificially generated skin wounds (control day 10) that was intensified by a local Vivostat PRF wound treatment on day 0 and day 5 of the conducted study. Scale bars represent 50 μm.

(a)

(b)