5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 10

Lack of 5-HT decreases the bacterial loads in CLP-induced sepsis. The mice were anesthetized, and the peritoneal fluid, blood, and lung tissue were collected to measure the bacterial loads 24 h after the CLP. The bacterial loads were significantly decreased in the KO-CLP mice compared with the WT-CLP mice in the peritoneal fluid, blood, and lung tissue. All data are expressed as the mean ± SD (, versus the WT-CLP group).