UDP-Induced Phagocytosis and ATP-Stimulated Chemotactic Migration Are Impaired in STIM1^−/− Microglia In Vitro and In Vivo

Figure 3

Chemotactic migration in wild-type and STIM1^−/− microglia. (a) Treatment with 50 μM ATP-induced changes in 2 mM Ca²⁺ media. (b) Time-dependent migration toward 50 μM ATP determined in chemotaxis chambers. Cells migrating toward ATP were fixed, stained with DAPI, and counted after 15, 30, 60, and 90 min. The numbers of migrating cells at each time point were determined from six independent experiments and are depicted graphically. , , and versus the corresponding control (, where is the number of independent experiments).

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