The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

Table 1

Typical surface markers and functions in M1 and M2 macrophages.

M1 markers	Major function	Ref.
CD80 (B7-1)	T cell activation and survival	[15]
CD86 (B7-2)	T cell activation and survival	[15]
MHC-II	Exogenous antigen presentation	[15]
CD11c	Phagocytosis	[17]
TLR4	Pathogen recognition	[18]
Mincle	Phagocytosis and proinflammatory cytokines	[18]
M2 markers	Major function
CD206	Phagocytosis, antigen presentation, and resolution of inflammation	[19]
CD163	Tolerance induction and tissue regeneration	[15]
Dectin-1	Chemotaxis	[15]
CD301	Cell adhesion, cell-cell signalling, and glycoprotein turnover	[21]
Arginase-1	Suppression of clearance of intracellular pathogens	[15]