Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway

Table 3

Values of biomarkers in the 5 days of measurements in median and interquartile ranges (25–75 percentiles).

Day	Median	IQR p25–75	Median	IQR p25–75
	IL-8 (pg/mL)		IL-12/23p40 (pg/mL)
1	89.9	32.8–243.2	63.7	30.6–203.8
2	46.2	19.2–133.4	67.3	10.4–110.9
3	24.9	13.5–58.6	77.2	34.5–162.8
5	20.5	13.5–50.7	66.2	26.3–128.5
14	16.3	8.9–24.6	132.6	51–191.9
	IL-6 (pg/mL)		IL-10 (pg/mL)
1	57.3	31–198.2	2.2	0.6–10.2
2	21.6	10.1–49.9	2.6	0.1–5.4
3	12.7	5.9–36	1.8	0.8–3.3
5	11.9	4.7–35.6	1.1	0–1.7
14	6.3	3.8–7.7	0.4	0–1.7
	IL-21 (pg/mL)		TNF-α (pg/mL)
1	0	0-0	0	0–2.65
2	0	0-0	0	0–1.5
3	0	0-0	0.6	0–2.5
5	0	0-0	0.3	0–1.7
14	0	0-0	1.7	0–2.8
	IL-1β (pg/mL)		G-CSF (pg/mL)
1	0	0-0	2182.7	282.7–5739.5
2	0	0	2350.2	356–4793.9
3	0	0	947.9	139.9–4125
5	0	0-0.5	177	31–2232.4
14	0	0	28.1	15.5–50
	IL-17 (pg/mL)		GM-CSF (pg/mL)
1	0	0–2.6	0.1	0–2.8
2	0.5	0–3.7	0.9	0–3.4
3	1.1	0–4.9	0.6	0–2.4
5	1.6	0–2.8	0.6	0–1.9
14	2.8	0.5–6.4	1.6	0.4–2
	C-reactive protein (mg/L)		Procalcitonin (pg/mL)
1	56	28.9–98	149.1	0–909.6
2	78.5	61.8–95.3
3	87.2	54.2–130.6
5	47.7	16.2–87.5
14	7.7	5.7–7.2