Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway

Table 7

Performance of cutoff values and combinations of the biomarkers IL-6, IL-8, IL-10, and PCT (all in pg/mL) as sepsis discriminators on day 1 of fever, compared with the high-risk assessment model. S = sensitivity; E = specificity; PPV = positive predictive value; NPV = negative predictive value; LR+ = positive likelihood ratio; LR− = negative likelihood ratio.

	IL-6 > 170	IL-8 > 240	PCT > 180	IL-10 > 6	High risk
S	0.69	0.69	0.80	0.69	1.00
E	0.95	1.00	0.68	0.86	0.44
PPV	0.90	1.00	0.50	0.75	0.42
NPV	0.84	0.85	0.89	0.83	1.00
LR+	9.00	−	1.00	3.00	0.71
LR−	0.19	0.18	0.12	0.21	0.00
Youden J	0.65	0.69	0.48	0.56	0.44
	IL-8 > 240 + high risk	PCT > 180 + high risk	IL-10 > 6 + PCT > 180	IL-8 > 100 + PCT > 100	IL-6 > 50 + PCT > 100
S	0.69	0.77	0.69	0.85	0.85
E	1.00	0.86	0.91	0.91	0.82
PPV	1.00	0.77	0.82	0.85	0.73
NPV	0.85	0.86	0.83	0.91	0.90
LR+	—	3.33	4.50	5.50	2.75
LR−	0.18	0.16	0.20	0.10	0.11
Youden J	0.69	0.63	0.60	0.76	0.66