NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

Figure 4

NLRP3 deletion decreases UUO-induced phenotypic alterations in UUO mice. Expression of α-SMA and E-cadherin protein detected in kidney samples from different groups (a). Semiquantitative analysis of α-SMA expression (b) and E-cadherin expression (c) normalized against β-actin. Data represent the mean ± SEM (). compared with WT/Sham group, , NLRP3^−/−/U14 group versus WT/U14 group. U1, U3, U7, and U14 indicate that mice were sacrificed on days 1, 3, 7, and 14 after UUO.

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