N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy

<div>Effects of NAC on apoptosis. (a) Myocardial cell apoptosis assessed by TUNEL, (b) ratio of Bax/Bcl-2, and (c) expression of cleaved-caspase-3. Ischemia reperfusion (I/R) was achieved by 30-minute ischemia followed by 2-hour reperfusion in diabetic rats with or without NAC. Ctrl: nondiabetic control; D4w: 4-week diabetes; D4w + I/R: 4 weeks’ diabetic rats with ischemia/reperfusion; D4w + I/R + NAC: 4 weeks’ diabetic rats treated with N-acetylcysteine (NAC) and were subjected to ischemia/reperfusion. 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Mediators of Inflammation

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Figure 3

Figure 3: N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy 