The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology

Figure 1

Common features of CF and COPD. CF and COPD lung disease share many common clinical manifestations despite the differences with respect to etiology. Mutations in the CFTR gene determine CF lung disease. Recently, CS has been shown to affect CFTR channel activity and this is recognized as a factor that may contribute to a CF-like phenotype in COPD. Thus, COPD has been recently described as “acquired CF.”