Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway

<div>Silibinin treatment ameliorated colitis and tumor load in AOM/DSS mice. (a) The experimental course of AOM/DSS mouse model. (b) Body weight changes of all groups after treatment. (c) Macroscopic appearance of colon in the control, AOM/DSS, and AOM/DSS/SB groups. (d) Colon length after treatment at day 70. (e) Colon weight after AOM/DSS induction at day 70. (f) Colon was opened longitudinally after sacrifice and the amount of tumors were calculated. (g, h) Histogram showing the size distribution of tumors and average tumor load. 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Mediators of Inflammation

fig1

Figure 1

Figure 1: Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway 