Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway

<div>Silibinin treatment suppressed colitis-associated tumorigenesis. (a) Hematoxylin and eosin (H&amp;E) staining of colon tumor and colitis in the control, AOM/DSS, and AOM/DSS/SB groups. Scale bars, 50 <i>μ</i>m. (b, c) Tumor score and colitis score of each group. 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443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.846,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>,</span> AOM/DSS vs. AOM/DSS/SB).</div>

Mediators of Inflammation

fig2

Figure 2

Figure 2: Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway 