Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway

<div>Silibinin decreased inflammatory cytokine production in intestinal tumor cell lines and AOM/DSS mice. (a, b) Real-time PCR was performed to detect the inflammatory cytokines in intestinal tumor cells. Relative expressions of IL-6, IL-1<i>β</i>, and TNF-<i>α</i> in IMCE (a) and HCT-116 cells (b) were presented. (c) Relative expression of IL-6, IL-1<i>β</i>, and TNF-<i>α</i> in colonic tumor-adjacent tissue in the control, AOM/DSS, and AOM/DSS/SB groups. Data were representative of three independent experiments and expressed as mean ± SD. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway 