Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway

<div>Silibinin downregulated IL-6/STAT3 pathway in AOM/DSS mice. (a, b) The expression of IL-6 in colonic tissues from the control, AOM/DSS, and AOM/DSS/SB mice was visualized by immunohistochemical staining. The percentage of IL-6 positive staining in five randomly selected fields of each group was shown. (c, f) STAT3 (c) and p-STAT3 (e) in colonic tissues from the three groups were detected. Positive rate of STAT3 (d) and p-STAT3 (f) in five randomly selected fields of each group was also presented separately. Scale bars, 50 <i>μ</i>m. 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Mediators of Inflammation

fig7

Figure 7

Figure 7: Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway 