Research Article

Immune Checkpoint Receptors Tim-3 and PD-1 Regulate Monocyte and T Lymphocyte Function in Septic Patients

Figure 3

Effects of the Tim-3 and PD-1 signaling pathway on the cytokines in the T lymphocytes and monocytes. (a) Expression of IL-10 in T lymphocytes after Tim-3 and PD-1 blockade. (b) Expression of TNF-α in T lymphocytes after Tim-3 and PD-1 blockade. (c) Proportion of IL-10-expressing monocytes after Tim-3 and PD-1 blockade. (d) Proportion of TNF-α-expressing monocytes after Tim-3 and PD-1 blockade. The data were analyzed by the Mann–Whitney test.
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