Maresins: Specialized Proresolving Lipid Mediators and Their Potential Role in Inflammatory-Related Diseases

Figure 1

Maresin biosynthetic pathway [48].The pathway is initiated by the lipoxygenation of DHA to yield 13S,14S-epoxy-maresin. This intermediate is then enzymatically hydrolyzed to maresin 1 or via a soluble epoxide hydrolase (sEH) to maresin 2. 13S,14S-epoxy-maresin is also a substrate for glutathione S-transferase MU 4 (GSTM4) and leukotriene C4 synthase (LTC4S) yielding MCTR1, which is then converted to MCTR2 by gamma-glutamyl transferase (GGT) and to MCTR3 by dipeptidase (DPEP).