Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease

Figure 1

Neutrophils are more activated in the peripheral blood and intestinal mucosa of active IBD patients. (a, b) Peripheral blood samples were collected from healthy donors (HC, ), patients with active CD (A-CD, ), patients with CD in remission (R-CD, ), patients with active UC (A-UC, ), and patients with UC in remission (R-UC, ). The whole blood excluding RBC was analyzed by flow cytometry. compared with HC. (c) Immunohistochemical staining of MPO in inflamed intestinal mucosa from healthy control (HC, ), patients with A-CD (), and patients with A-UC (). The arrows indicate MPO⁺ cells. Original magnification × 200. compared with HC.

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