Notch1 Signaling Regulates the Th17/Treg Immune Imbalance in Patients with Psoriasis Vulgaris

Figure 5

The percentages of Th17 cells (a), RORγt mRNA (d), and IL-17 mRNA (g) expression in cultured CD4⁺ T cells, as well as IL-17 concentrations (h) in cell-free supernatant decreased obviously in a dose-dependent manner after DAPT treatment (all ), and the same characteristics could be seen in the ratio of Th17/Treg (c) and the ratio of RORγt/Foxp3 (f). However, there was no significant difference in Treg cell percentage (b), Foxp3 mRNA expression (e), IL-10 mRNA expression (i), and IL-10 concentrations (j) after DAPT treatment (all ).

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