Research Article
Titanium Ions Promote Exogenous Calcium-Dependent Calcium Influx in Activated Jurkat T Cells: A Possible Mechanism to Explain Its Immunostimulatory Properties
Figure 5
Flow cytometric measurement of calcium influx after long-term treatment with Ti(IV) ions. Jurkat T cells were stimulated with, or without, PHA for 24 h and treated with the indicated doses of Ti(IV) for 24 h in the presence of exogenous calcium or EGTA. (a, b) The levels of [Ca2+]i in activated cells. (c, d) The levels of [Ca2+]i in unactivated cells. Data are expressed as the mean ± SD of each group from three separate experiments and differences between mean values were assessed by one-way ANOVA. indicates a statistically significant difference compared with the control group.
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