Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation

Figure 3

Increased M1/M2 macrophage ratio in the imiquimod-induced psoriatic lesions. Balb/c mice were treated with imiquimod (IMQ) for 5 days as illustrated in Figure 2(a). Macrophages in the tissues were analyzed by flow cytometer. (a, b) A set of representative histograms is shown for the gated population of F4/80-positive macrophages, F4/80 CD86 double-positive M1 macrophages, and F4/80 CD206 double-positive M2 macrophages in tissues from (a) control and (b) IMQ-treated mice. (c) The ratio of M1 and M2 macrophages in tissues from control- and IMO-treated mice was calculated from the bar figures in (a) and (b). Bar figures: the data represent mean ± standard deviation (), .

(a)

(b)

(c)