Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis

Figure 4

Sophocarpine improves injury of LPS-treated hepatic stellate cells (HSCs) by suppressing apoptosis. (a–f) Sophocarpine decreased the mRNA expression of PI3K, AKT, Cyto-C, Apaf1, caspase-9, and caspase-3 analyzed by real-time PCR; the data are expressed as mean ± SEM, . (g) Evaluation of apoptosis in HSCs by TUNEL assays and number of TUNEL-positive cells was calculated under a microscope; the data are expressed as mean ± SEM, .

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