Transcriptional Profiling Suggests Extensive Metabolic Rewiring of Human and Mouse Macrophages during Early Interferon Alpha Responses

Figure 2

Metabolic genes are top classifiers of IFN-α stimulation in BMM and MDM. (a) Pathway enrichment and topology analysis of mouse BMM and human MDM following IFN-α stimulation (). Analyses were performed using all metabolic genes. The blue bars represent enrichment analysis. The yellow bars represent topology scores. (b) Top metabolic classifiers of IFN-α stimulation were identified using variable importance in projection (VIP) scores based on PLS-DA models (). Analyses were performed using all metabolic genes (). Red and green in the heat map represent upregulation and downregulation of gene expression, respectively.

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