Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice

Figure 6

Alloxan diabetes attenuates AHR caused by OVA challenge in sensitized mice. The AHR to aerosolized methacholine was measured 24 h after the last allergen challenge in unrestrained conscious mice. Mice were placed in the main chamber and aerosolized first with PBS followed by increasing doses of methacholine (3 and 6 mg/mL), 2 min for each aerosolization. Readings of breathing parameters were taken for 5 min after each nebulization during which Penh values were determined. Each value indicates the mean ± SEM from five animals per group. and versus nondiabetic saline-challenged mice; and versus nondiabetic OVA-challenged mice.