Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism

<div>LPS-induced expression of MMP2 and MMP9 is increased by sesn2 knockdown in H9c2 cells. (a and b) Sesn2 knockdown cells were stimulated with LPS or LPS plus AICAR for 6 h, after which Western blotting was performed to assess the levels of MMP2 and MMP9. All graphs were obtained from three independent experiments. 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Mediators of Inflammation

fig3

Figure 3

Figure 3: Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism 

Figure 3 | Knockdown of Sestrin2 Increases Lipopolysaccharide-Induced Oxidative Stress, Apoptosis, and Fibrotic Reactions in H9c2 Cells and Heart Tissues of Mice via an AMPK-Dependent Mechanism 