PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury

Figure 5

PICK1 participates in autophagy through dephosphorylation of Akt and mTOR. (a) Representative Western blot images and statistical analysis of p-Akt/t-Akt and p-mTOR/t-mTOR levels in PICK1^−/− mice. Results represent the mean ± SEM of independent experiments in mice (). vs. sham-operated group, vs. CLP group.

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